反应详情

温度

81 °C

Sodium methoxide (571 mg, 1.05 mmol) was added to a solution of 5-chloro-8-nitroquinoline (Intermediate 65) (550 mg, 2.64 mmol) in MeOH (15 ml) and heated to 81° C. for 2 h. After cooling, the mixture was concentrated in vacuo, water was added and the mixture was extracted with DCM. The organic phase was dried (Na2SO4) and concentrated in vacuo gave the title compound (500 mg, 93%). The structure was confirmed by 1H NMR.

1. temperatureAfter cooling
2. concentrationthe mixture was concentrated in vacuo, water
3. additionwas added
4. extractionthe mixture was extracted with DCM
5. dry with materialThe organic phase was dried (Na2SO4)
6. concentrationconcentrated in vacuo