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6-Methoxy-8-quinolinamine → 4-chloro-2-fluoro-N-(6-methoxyquinolin-8-yl)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methoxy-8-quinolinamine | HCID 7023 | — |
| 反応物 | 4-Chloro-2-fluorobenzene-1-sulfonyl chloride | HCID 2778860 | — |
| 生成物 | 4-chloro-2-fluoro-N-(6-methoxyquinolin-8-yl)benzenesulfonamide | HCID 60163923 | 56% |
反応手順
In a similar fashion using route 14 general procedure 26, 6-methoxyquinolin-8-amine (Intermediate 23) (60 mg, 0.35 mmol), 2-fluoro-4-chlorobenzenesulfonyl chloride (100 mg, 0.45 mmol) gave the title compound (70 mg, 56%) after purification by column chromatography with DCM as the eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09102688B2 |
| 出典データセット | uspto-grants-2015_08 |
| ORD ID | ord-927956a61f0c4fee8473d556af9add27 |
| 出典メモ | uspto-grants-2015_08 |