HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Chloroquinolin-8-amine → Pyridine-3-sulfonic acid (5-chloro-quinolin-8-yl)-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Edukt | Pyridine-3-sulfonyl chloride | HCID 3164136 | — |
| Produkt | Pyridine-3-sulfonic acid (5-chloro-quinolin-8-yl)-amide | HCID 60163925 | 43% |
Reaktionsschritte
In a similar fashion using route 14 general procedure 26, 5-chloroquinolin-8-amine (Intermediate 27) (50 mg, 0.28 mmol), pyridine-3-sulfonyl chloride (Intermediate 17) (74 mg, 0.42 mmol) gave the title compound (38 mg, 43%) after purification by column chromatography with DCM as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-c4a79b7e147d4d16b8f43312146177be |
| Quellennotiz | uspto-grants-2015_08 |