HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(4-Chloro-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 4-Chloroquinolin-8-amine | HCID 12604274 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(4-Chloro-quinolin-8-yl)-benzenesulfonamide | HCID 68183402 | 61.3% |
Reaction Steps
In a similar fashion using route 14 general procedure 26, 4-chloro-quinolin-8-ylamine 464 (228 mg, 1.28 mmol), benzenesulfonyl chloride (0.2 ml, 1.53 mmol) pyridine (0.21 ml, 2.56 mmol) in DCM (10 ml) gave the title compound (250 mg, 61%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-dbf80136288040ceab2bd36e03d931ce |
| Source note | uspto-grants-2015_08 |