HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → N-Quinolin-8-yl-3-trifluoromethoxy-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 3-(Trifluoromethoxy)benzene-1-sulfonyl chloride | HCID 2777218 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-Quinolin-8-yl-3-trifluoromethoxy-benzenesulfonamide | HCID 31779790 | 60% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), 3-trifluoromethoxybenzenesulfonyl chloride (200 mg, 0.69 mmol) and DMAP (cat.) gave the title compound (150 mg, 60%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-53380fbf913b4294a2818302b4b5c24b |
| Source note | uspto-grants-2015_08 |