HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → 4-chloro-2-fluoro-N-(quinolin-8-yl)benzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 4-Chloro-2-fluorobenzene-1-sulfonyl chloride | HCID 2778860 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 4-chloro-2-fluoro-N-(quinolin-8-yl)benzene-1-sulfonamide | HCID 8823696 | 82% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), 4-chloro-2-fluorobenzenesulfonyl chloride (200 mg, 0.83 mmol) and DMAP (cat.) gave the title compound (190 mg, 82%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5b4fb98268aa45a99e79739ed819b0cd |
| Source note | uspto-grants-2015_08 |