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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 513453Generated: November 3, 2026

8-Aminoquinoline → N-(Quinolin-8-yl)-3-trifluoromethylbenzenesulfonamide

https://huagongshe.com/reaction/513453

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-AminoquinolineHCID 11359—
Reactant3-(Trifluoromethyl)benzenesulfonyl chlorideHCID 2733250—
Catalyst4-(Dimethylamino)pyridineHCID 14284—
ProductN-(Quinolin-8-yl)-3-trifluoromethylbenzenesulfonamideHCID 3863015100.4%

Reaction Steps

In the similar fashion using route 14 general procedure 27, 8-aminoquinoline (100 mg, 0.69 mmol), 3-trifluoromethylbenzenesulfonyl chloride (200 mg, 0.83 mmol) and DMAP (cat.) gave the title compound (244 mg, 100%) after purification by column chromatography with DCM as the eluent.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09102688B2
Source datasetuspto-grants-2015_08
ORD IDord-2da3a563d63549a68eebb40c497bc519
Source noteuspto-grants-2015_08