HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → 6-Cyano-pyridine-3-sulfinic acid quinolin-8-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 6-Cyanopyridine-3-sulfonyl chloride | HCID 47003190 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 6-Cyano-pyridine-3-sulfinic acid quinolin-8-ylamide | HCID 68183116 | 26.9% |
Reaction Steps
In a similar fashion using route 18 general procedure 27, 8-aminoquinoline (200 mg, 1.39 mmol), 6-cyanopyridine-3-sulfonyl chloride 19 (337 mg, 1.66 mmol) and DMAP (cat.) gave the title compound (110 mg, 25%) after purification by column chromatography with n-hexane/EtOAc (4:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-37eec6288a844527a0c3f7253ecf11ed |
| Source note | uspto-grants-2015_08 |