HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → 6-Trifluoromethyl-pyridine-3-sulfonic acid quinolin-8-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 6-(Trifluoromethyl)pyridine-3-sulfonyl chloride | HCID 45594311 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 6-Trifluoromethyl-pyridine-3-sulfonic acid quinolin-8-ylamide | HCID 68183194 | 58% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoquinoline (200 mg, 1.38 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (0.31 g, 1.25 mmol) and DMAP (cat) gave the title compound (250 mg, 58%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-fe78b1c192e04fbaab44011a25af1c45 |
| Source note | uspto-grants-2015_08 |