HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(2-methylquinolin-8-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 2-Methyl-8-aminoquinoline | HCID 140457 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(2-methylquinolin-8-yl)benzenesulfonamide | HCID 2848041 | 43% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 2-methyl-8-aminoquinoline (Intermediate 22) (200 mg, 1.2 mmol), benzenesulfonyl chloride (230 mg, 1.2 mmol) and DMAP (cat.) gave the title compound (150 mg, 43%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-e2a79950bf3740699f7a9a2b8d9a89f0 |
| Source note | uspto-grants-2015_08 |