HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-8-quinolinamine → N-(6-methoxyquinolin-8-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-8-quinolinamine | HCID 7023 | — |
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(6-methoxyquinolin-8-yl)benzenesulfonamide | HCID 821430 | 63.6% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 6-methoxyquinolin-8-amine (Intermediate 23) (250 mg, 1.43 mmol), benzenesulfonyl chloride (220 μl, 1.3 mmol) and DMAP (cat.) gave the title compound (260 mg, 57%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-ce87dcc548354721babfa6a555306cf7 |
| Source note | uspto-grants-2015_08 |