HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(2-Chloroquinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 2-Chloroquinolin-8-amine | HCID 346519 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(2-Chloroquinolin-8-yl)-benzenesulfonamide | HCID 86669756 | 88.5% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 2-chloroquinolin-8-amine (Intermediate 26) (70 mg, 0.39 mmol), benzenesulfonyl chloride (83 mg, 0.42 mmol) and DMAP (cat.) gave the title compound (110 mg, 88%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7e15a17fd9cc4e70b07365bb593ad043 |
| Source note | uspto-grants-2015_08 |