HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(5-chloroquinolin-8-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(5-chloroquinolin-8-yl)benzenesulfonamide | HCID 3596728 | 64.3% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 5-chloroquinolin-8-amine (Intermediate 27) (70 mg, 0.39 mmol), benzenesulfonyl chloride (83 mg, 0.42 mmol) and DMAP (cat.) gave the title compound (80 mg, 64%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-69f60a8478cd434d913b9a3827e82611 |
| Source note | uspto-grants-2015_08 |