HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-5-Methylquinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 5-Methylquinolin-8-amine | HCID 12846625 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-5-Methylquinolin-8-yl-benzenesulfonamide | HCID 68182878 | 28.2% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5-methylquinolin-8-amine (Intermediate 44) (150 mg, 0.95 mmol) and benzenesulfonyl chloride (200 mg, 1.14 mmol) gave the title compound (80 mg, 28%) after column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-9ebed34b7eba4396b37f1b42dfca45db |
| Source note | uspto-grants-2015_08 |