HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-fluorobenzene-1-sulfonyl chloride → 4-Chloro-2-fluoro-N-(6-fluoroquinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-fluorobenzene-1-sulfonyl chloride | HCID 2778860 | — |
| Reactant | 6-Fluoroquinolin-8-amine | HCID 13227992 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | 4-Chloro-2-fluoro-N-(6-fluoroquinolin-8-yl)-benzenesulfonamide | HCID 68183259 | 43% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-amine (Intermediate 48) (150 mg, 0.93 mmol), 4-chloro-2-fluorobenzenesulfonyl chloride (250 mg, 1.11 mmol) and DMAP (cat.) gave the title compound (140 mg, 43%) after purification by column chromatography with DCM/n-hexane (4:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-80d9341615dd4f11882c2998d1f3d18b |
| Source note | uspto-grants-2015_08 |