HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → HCID 68183477, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | HCID 68183325 | HCID 68183325 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | HCID 68183477 | HCID 68183477 | 35% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5,6-difluoroquinolin-8-amine (Intermediate 49) (120 mg, 0.67 mmol), benzenesulfonyl chloride (141 mg, 0.78 mmol) and DMAP (cat.) gave the title compound (73 mg, 35%) after purification by column chromatography with n-hexane/EtOH (1:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2e0a2612329d4bf0b88c50aa3ae64af2 |
| Source note | uspto-grants-2015_08 |