HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(5-Chloro-6-fluoro-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 5-Chloro-6-fluoroquinolin-8-amine | HCID 68183007 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(5-Chloro-6-fluoro-quinolin-8-yl)-benzenesulfonamide | HCID 68183168 | 16% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5-chloro-6-fluoroquinolin-8-amine (Intermediate 53) (100 mg, 0.51 mmol), benzenesulfonyl chloride (100 mg, 0.61 mmol) and DMAP (cat.) gave the title compound (27 mg, 16%) after purification by column chromatography with DCM as the eluent followed by preparative HPLC (neutral conditions).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-6e5b955f828b41988352d00c875dc99e |
| Source note | uspto-grants-2015_08 |