HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-(5,6-Dimethyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 8-Quinolinamine, 5,6-dimethyl- | HCID 110465 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | N-(5,6-Dimethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183094 | 10% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5,6-dimethylquinolin-8-amine (Intermediate 55) (60 mg, 0.38 mmol), benzenesulfonyl chloride (72 mg, 0.41 mmol) and DMAP (cat.) gave the title compound (10 mg, 10%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-893bf035e9c143b9ad62ba861d2ccc05 |
| Source note | uspto-grants-2015_08 |