HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 68183235, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 5-TRIFLUOROMETHYL-PYRIDINE-3-SULFONYL CHLORIDE | HCID 55279364 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68183235 | HCID 68183235 | 17.7% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoquinoline (70 mg, 0.48 mmol), 5-trifluoromethyl-pyridine-3-sulfonyl chloride (Intermediate 442) (153 mg, 0.63 mmol), DMAP (cat.), pyridine (1.5 ml) and DCM (2 ml) gave the title compound (30 mg, 11%) after purification by column chromatography with n-hexane/EtOAc (85:15) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-31f169e4bc9d45299c0b9a0217f75be3 |
| Source note | uspto-grants-2015_08 |