HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Trifluoromethyl-pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 6-(Trifluoromethyl)pyridine-3-sulfonyl chloride | HCID 45594311 | — |
| Reactant | 6-(Trifluoromethoxy)quinolin-8-amine | HCID 68183001 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Trifluoromethyl-pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide | HCID 60164192 | 42.9% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-trifluoromethoxy-quinolin-8-ylamine (Intermediate 46) (75 mg, 0.32 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (96 mg, 0.39 mmol), DMAP (cat.), pyridine (0.05 ml, 0.65 mmol) and DCM (2 ml) gave the title compound (60 mg, 42%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-0b006ee69deb445fafad0e141b5a9790 |
| Source note | uspto-grants-2015_08 |