HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Trifluoromethyl-pyridine-3-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | — |
| Reactant | 6-(Trifluoromethyl)pyridine-3-sulfonyl chloride | HCID 45594311 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Trifluoromethyl-pyridine-3-sulfonic acid (5-trifluoromethyl-quinolin-8-yl)-amide | HCID 60164193 | 13% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5-trifluoromethyl-quinolin-8-ylamine (Intermediate 45) (100 mg, 0.47 mmol), 6-(trifluoromethyl)pyridine-3-sulfonyl chloride (138 mg, 0.56 mmol), pyridine (0.08 ml, 0.94 mmol), DMAP (cat.) and DCM (5 ml) gave the title compound (25 mg, 13%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-a6758c5aaf494fababd9e0ff641c2435 |
| Source note | uspto-grants-2015_08 |