HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → Pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Pyridine-3-sulfonyl chloride | HCID 3164136 | — |
| Reactant | 6-(Trifluoromethoxy)quinolin-8-amine | HCID 68183001 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Pyridine-3-sulfonic acid (6-trifluoromethoxy-quinolin-8-yl)-amide | HCID 68190278 | 85% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-(trifluoromethoxy)quinolin-8-ylamine (Intermediate 46) (110 mg, 0.48 mmol), pyridine-3-sulfonyl chloride (Intermediate 17) (102 mg, 0.57 mmol), pyridine (0.08 ml, 0.96 mmol), DMAP (cat.) and DCM (5 ml) gave the title compound (150 mg, 85%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-005c514a1b724aa8b15db77f878710a4 |
| Source note | uspto-grants-2015_08 |