HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Cyano-pyridine-3-sulfonic acid (6-fluoro-quinolin-8-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 6-Fluoroquinolin-8-amine | HCID 13227992 | — |
| Reactant | 6-Cyanopyridine-3-sulfonyl chloride | HCID 47003190 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Cyano-pyridine-3-sulfonic acid (6-fluoro-quinolin-8-yl)-amide | HCID 60164306 | 26.5% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 6-fluoroquinolin-8-ylamine (Intermediate 48) (125 mg, 0.77 mmol), 6-cyano-pyridine-3-sulfonyl chloride (Intermediate 19) (187 mg, 0.92 mmol), pyridine (121 mg, 1.54 mmol), DMAP (cat.) and DCM (10 ml) gave the title compound (67 mg, 26%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-af9ab1f2fc444e40adce37500901a79e |
| Source note | uspto-grants-2015_08 |