HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-Quinazolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | Quinazolin-8-amine | HCID 11344089 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-Quinazolin-8-yl-benzenesulfonamide | HCID 68183159 | 54% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, quinazolin-8-ylamine (Intermediate 480) (60 mg, 0.41 mmol), benzene sulfonyl chloride (94 mg, 0.53 mmol), DMAP (cat.) and pyridine (1 ml) at 150° C. for 2.5 h, gave title compound (30 mg, 54%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d02682ed30fd476699b2ef2996eb93af |
| Source note | uspto-grants-2015_08 |