HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Aminoquinoline → 4-Methoxy-2-nitro-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 4-Methoxy-2-nitrobenzenesulphonyl chloride | HCID 87452 | — |
| Product | 4-Methoxy-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 16759547 | 74% |
Reaction Steps
In a similar fashion using route 14 general procedure 26, 8-aminoquinoline (220 mg, 2 mmol) and 4-methoxy-2-nitrobenzene-1-sulfonyl chloride (420 mg, 2 mmol) gave the title compound (406 mg, 74%) after purification by column chromatography with heptane/EtOAc (50:50-0:100) gradient elution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8eba55832ccc4c20aca7183249b5ec11 |
| Source note | uspto-grants-2015_08 |