HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-8-quinolinamine → N-(6-methoxyquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-8-quinolinamine | HCID 7023 | — |
| Reactant | 2-Nitro-p-toluenesulphonyl chloride | HCID 104689 | — |
| Product | N-(6-methoxyquinolin-8-yl)-4-methyl-2-nitrobenzenesulfonamide | HCID 16759965 | 58.2% |
Reaction Steps
In a similar fashion using route 14 general procedure 26, 6-methoxyquinolin-8-amine (Intermediate 23) (120 mg, 0.69 mmol) and 4-methyl-2-nitrobenzenesulfonyl chloride (Intermediate 20) (186 mg, 1.03 mmol) gave the title compound (150 mg, 58%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-eda6e5b1ee484c98ac736c33d49651ee |
| Source note | uspto-grants-2015_08 |