HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Chloroquinolin-8-amine → N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Edukt | 2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 2775780 | — |
| Produkt | N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide | HCID 68182997 | 99,3% |
Reaktionsschritte
In a similar fashion using route 14 general procedure 26, 5-chloroquinolin-8-amine (Intermediate 27) (50 mg, 0.28 mmol), 2-nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride (162 mg, 0.56 mmol) gave the title compound (120 mg, 50%) after purification by column chromatography with DCM as the eluent.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09102688B2 |
| Quelldatensatz | uspto-grants-2015_08 |
| ORD ID | ord-2ab982025e0942ceae1bf14906624934 |
| Quellennotiz | uspto-grants-2015_08 |