HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Nitro-N-quinoxalin-5-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | 5-Aminoquinoxaline | HCID 85494 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Nitro-N-quinoxalin-5-yl-benzenesulfonamide | HCID 68183354 | 56% |
Reaction Steps
In a similar fashion using route 14 general procedure 26, quinoxalin-5-ylamine (Intermediate 482) (540 mg, 3.7 mmol), 2-nitro-benzenesulfonyl chloride (986 mg, 4.46 mmol), pyridine (0.9 ml, 7.44 mmol) and DCM (10 ml) gave the title compound (679 mg, 56%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-7512a3a30b974f92835ebd98f46493a2 |
| Source note | uspto-grants-2015_08 |