2-Nitrobenzenesulfonyl chloride → HCID 68183129, compound

HRID 513513Notes

Reaction equation

HRID 513513 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([NH2:12])[CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2.[N+:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22](Cl)(=[O:24])=[O:23])([O-:15])=[O:14]>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([NH:12][S:22]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[N+:13]([O-:15])=[O:14])(=[O:23])=[O:24])[CH:11]=1)[N:8]=[CH:7][CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 155402-Nitrobenzenesulfonyl chlorideHCID 132279926-Fluoroquinolin-8-amine2×

Product 1

HCID 68183129HCID 68183129, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In a similar fashion using route 14 general procedure 26, 6-fluoroquinolin-8-ylamine (Intermediate 48) (320 mg, 1.97 mmol), 2-nitro-benzenesulfonyl chloride (523 mg, 2.37 mmol), pyridine (2 ml) for 16 h gave the title compound (520 mg, 76%) which was used in the next step without further purification.

Workup

  1. customfor 16 h

Sources & evidence

ORD record
ord-9199ac46284747d9aa6644f5e11f94f0
Source dataset
uspto-grants-2015_08
Patent number
US09102688B2

Reaction notes

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