HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(5-Chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Nitrobenzenesulfonyl chloride | HCID 15540 | — |
| Reactant | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-Chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68183417 | 79% |
Reaction Steps
In a similar fashion using route 14 general procedure 26, 5-chloro-quinolin-8-ylamine (Intermediate 27) (380 mg, 2.13 mmol), 2-nitrobenzene-1-sulfonyl chloride (566 mg, 2.56 mmol), pyridine (0.34 ml, 4.26 mmol) and DCM (12 ml) gave the title compound (610 mg, 79%) after purification by column chromatography with n-hexane/DCM (1:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-22d9b719a2724a2c9f738fc071deb19d |
| Source note | uspto-grants-2015_08 |