HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 35532075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | methyl 4-(chlorosulfonyl)-3-nitrobenzoate | HCID 11208244 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 35532075 | HCID 35532075 | 40% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (0.60 g, 4.16 mmol), 4-chlorosulfonyl-3-nitro-benzoic acid methyl ester (Intermediate 438) (1.5 g, 5.41 mmol), DMAP (cat), pyridine (6 ml) and DCM (3 ml) gave the title compound (0.65 g, 40%) after purification by column chromatography with n-hexane/EtOAc (80:20) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-47545e17e76d4ef5a06fadb90f708cbc |
| Source note | uspto-grants-2015_08 |