HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Chloro-2-nitro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Chloro-2-nitrophenylsulfonyl chloride | HCID 20631 | — |
| Reactant | 8-Quinolinamine, 4-(trifluoromethyl)- | HCID 68183204 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-2-nitro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183199 | 60.5% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 4-trifluoromethyl-quinolin-8-ylamine (Intermediate 469) (325 mg, 1.53 mmol), 4-chloro-2-nitrobenzenesulfonylchloride (Intermediate 454) (507 mg, 1.99 mmol), DMAP (cat.), pyridine (0.5 ml), and DCM (5 ml) gave the title compound (400 mg, 60%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-4165ea35cb9a4699b0a3fd14bbcb6519 |
| Source note | uspto-grants-2015_08 |