HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Chloro-2-nitro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Chloro-2-nitrophenylsulfonyl chloride | HCID 20631 | — |
| Reactant | 8-Quinolinamine, 5-(trifluoromethyl)- | HCID 10353118 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-2-nitro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183145 | 46.8% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 5-trifluoromethyl-quinolin-8-ylamine (Intermediate 45) (390 mg, 1.83 mmol), 4-chloro-2-nitrobenzene-1-sulfonyl chloride (Intermediate 454) (565 mg, 2.22 mmol), DMAP(cat) and pyridine (0.3 ml, 5.55 mmol) in DCM (7 ml) gave the title compound (370 mg, 46%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-3a153beaa9a44a26b011791dece1f161 |
| Source note | uspto-grants-2015_08 |