HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-Chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-2-nitro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Reactant | 5-Chloro-4-fluoro-2-nitrobenzene-1-sulfonyl chloride | HCID 86669752 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Chloro-N-(5-chloro-quinolin-8-yl)-4-fluoro-2-nitro-benzenesulfonamide | HCID 68183435 | 12% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, using 5-chloro-quinolin-8-ylamine (Intermediate 27) (750 mg, 4.2 mmol), 5-chloro-4-fluoro-2-nitro-benzenesulfonyl chloride (Intermediate 218) (1.5 g, 5.4 mmol), DMAP (cat), pyridine (8 ml) and DCM (15 ml) gave the title compound (210 mg, 12%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-58eb0219c1cd44f6a8d948ffeae68c82 |
| Source note | uspto-grants-2015_08 |