HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Chloro-N-(2-chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Chloro-2-nitrophenylsulfonyl chloride | HCID 20631 | — |
| Reactant | 2-Chloroquinolin-8-amine | HCID 346519 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-N-(2-chloro-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 86669758 | 23% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 4-chloro-2-nitrobenzene-1-sulfonyl chloride (Intermediate 454) (0.86 g, 3.37 mmol), 2-chloro-quinolin-8-ylamine (Intermediate 26) (0.5 g, 2.80 mmol), DMAP (cat), pyridine (0.68 ml, 8.42 mmol) and DCM (10 ml) gave the title compound (0.25 g, 23%) after purification by column chromatography DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-bd6cc266440b49bf954edfde8140fce7 |
| Source note | uspto-grants-2015_08 |