HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloroquinolin-8-amine → HCID 68183167, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Reactant | HCID 61728228 | HCID 61728228 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 68183167 | HCID 68183167 | 70.7% |
Reaction Steps
In the similar fashion using route 14 general procedure 27, 5-chloro-quinolin-8-ylamine (Intermediate 27) (200 mg, 1.12 mmol), 4-methanesulfonyl-2-nitro-benzenesulfonyl chloride (Intermediate 439) (456 mg, 1.46 mmol), DMAP (cat.) and pyridine (5 ml) gave the title compound (350 mg, 60%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-53315d8e69444474ab872ff52327fc5f |
| Source note | uspto-grants-2015_08 |