HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-methyl-2-nitro-N-quinolin-8-ylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | 2-Nitro-p-toluenesulphonyl chloride | HCID 104689 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-methyl-2-nitro-N-quinolin-8-ylbenzenesulfonamide | HCID 973504 | 45% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoquinoline (1.4 g, 9.72 mmol), 4-methyl-2-nitro-benzenesulfonyl chloride (Intermediate 448) (2.97 g, 12.6 mmol), pyridine (7 ml) DMAP (cat.) and DCM (30 ml) gave the title compound (1.5 g, 45%), after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-af5d315faa6c443982b00e6ef298359c |
| Source note | uspto-grants-2015_08 |