HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 5-Methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 8-Aminoquinoline | HCID 11359 | — |
| Reactant | HCID 55279901 | HCID 55279901 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide | HCID 68183157 | 12.1% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoquinoline (0.350 g, 2.4 mmol), 5-methyl-2-nitro-benzenesulfonyl chloride (Intermediate 449) (0.86 g, 3.6 mmol), pyridine (1 ml) DMAP (cat) and DCM (5 ml) gave the title compound (100 mg, 12%) after purification by column chromatography with n-hexane/EtOAc (10:90) as the eluent. The structure was confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-fbed180d70bf4e08b39c9a588b84731e |
| Source note | uspto-grants-2015_08 |