HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 68183041, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 1227587-90-7 | HCID 86669760 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68183041 | HCID 68183041 | 32% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (550 mg, 3.8 mmol), 2-nitro-5-trifluoromethyl-benzenesulfonyl chloride (Intermediate 453) (1.43 g, 4.9 mmol), DMAP (cat.), pyridine (4 ml) and DCM (5 ml) gave the title compound (490 mg, 32%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5ab8e55d5d5e4550b3b5213f456a4fec |
| Source note | uspto-grants-2015_08 |