HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Nitro-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Nitro-4-trifluoromethoxy-benzenesulfonyl chloride | HCID 86669754 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Nitro-N-quinolin-8-yl-4-trifluoromethoxy-benzenesulfonamide | HCID 68183243 | 35% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 8-aminoqunoline (500 mg, 3.47 mmol), 2-nitro-4-trifluoromethoxy-benzenesulfonyl chloride (Intermediate 221) (1.4 g, 4.51 mmol), pyridine (5 ml), DMAP (cat.) and DCM (3 ml) gave the title compound (500 mg, 35%) after purification by column chromatography with n-hexane/EtOAc (90:10) as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d5b22ca0eeef4f01bf65499d9acfda36 |
| Source note | uspto-grants-2015_08 |