HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 5-Chloroquinolin-8-amine | HCID 224860 | — |
| Reactant | 2-Nitro-4-(trifluoromethyl)benzene-1-sulfonyl chloride | HCID 2775780 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-Chloroquinolin-8-yl)-2-nitro-4-trifluoromethylbenzenesulfonamide | HCID 68182997 | 45.3% |
Reaction Steps
In a similar fashion using route 14 general procedure 27, 2-nitro-4-trifluoromethylbenzenesulfonyl chloride (Intermediate 461) (1.24 g, 4.29 mmol), 5-chloro-quinolin-8-ylamine (Intermediate 27) (0.64 g, 3.58 mmol), DMAP (cat.), pyridine (0.86 ml, 10.7 mmol) and DCM (5 ml) gave the title compound (700 mg, 45%) after purification by column chromatography with DCM as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-50f8ccd6883f4ba0b36ff66f110f127e |
| Source note | uspto-grants-2015_08 |