4-Chloro-2-nitrophenylsulfonyl chloride → 4-Chloro-N-(5-cyano-quinolin-8-yl)-2-nitro-benzenesulfonamide

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Reaction Steps

In a similar fashion using route 14 general procedure 58, 8-aminoquinoline-5-carbonitrile (Intermediate 472) (100 mg, 0.5 mmol), 4-chloro-2-nitrobenzenesulfonyl chloride (Intermediate 454) (166 mg, 0.65 mmol), NaH (60% dispersion in mineral oil, 26 mg, 0.65 mmol) and THF (2 ml) gave the title compound (60 mg, 26%) after purification by column chromatography with n-hexane/DCM (50:50) as the eluent.

Provenance & Evidence