Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous chloride dihydrate → 2-Amino-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | N-(2-Methyl-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 16759518 | — |
| 생성물 | 2-Amino-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide | HCID 16759519 | 47.2% |
반응 단계
In a similar fashion using route 15 general procedure 29, N-(2-methyl-quinolin-8-yl)-2-nitro-benzenesulfonamide (Intermediate 149) (423 mg, 1.23 mmol) and tin (II) chloride dihydrate (701 mg, 3.70 mmol) gave the title compound (182 mg, 47%) after purification by column chromatography with DCM/MeOH (99:1-95:5) gradient elution.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09102688B2 |
| 출처 데이터셋 | uspto-grants-2015_08 |
| ORD ID | ord-d6f5f4abbf844d54b5441aec58f8437d |
| 출처 메모 | uspto-grants-2015_08 |