HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Nitro-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide | HCID 23631949 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Product | 2-Amino-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide | HCID 16759948 | 72.8% |
Reaction Steps
In the similar fashion using route 1 general procedure 4, 2-nitro-4-methoxy-N-(2-methyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 150) (550 mg, 1.4 mmol), tin (II) chloride (838 mg, 4.4 mmol) and 6N HCl (2 drops) gave the title compound (350 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5dd526d5e3644a9fa774717be4640a27 |
| Source note | uspto-grants-2015_08 |