HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-4-methyl-N-quinolin-8-yl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-methyl-2-nitro-N-quinolin-8-ylbenzenesulfonamide | HCID 973504 | — |
| Product | 2-Amino-4-methyl-N-quinolin-8-yl-benzenesulfonamide | HCID 16759922 | 17.2% |
Reaction Steps
In the similar fashion using route 1 general procedure 4, 4-methyl-2-nitro-N-quinolin-8-yl-benzenesulfonamide (Intermediate 151) (3.2 g, 9.3 mmol), tin (II) chloride (5.3 g, 2.79 mmol) and 6N HCl (2 ml) gave the title compound (500 mg, 17%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-5a2d012f7a3545edb968e522faa331dc |
| Source note | uspto-grants-2015_08 |