HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 2-Nitro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183341 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183487 | 81.7% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 2-nitro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 251) (0.4 g, 1.0 mmol), SnCl2 (0.76 g, 4.03 mmol), 6N HCl (2 drops) and EtOH (15 ml) gave the title compound (300 mg, 81%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d495ee170e7744a8acffbdb0a91b5f6f |
| Source note | uspto-grants-2015_08 |