HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-4-chloro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-Chloro-2-nitro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183199 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4-chloro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183002 | 100.7% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 4-chloro-2-nitro-N-(4-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 252) (365 mg, 0.84 mmol), SnCl2 (637 mg, 3.37 mmol), 6N HCl (2 drops) and EtOH (15 ml) gave the title compound (340 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-bd8512a7ebc64220949c8ba195a3646a |
| Source note | uspto-grants-2015_08 |