HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-4-chloro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-Chloro-2-nitro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183145 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4-chloro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide | HCID 68183350 | 98.4% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 4-chloro-2-nitro-N-(5-trifluoromethyl-quinolin-8-yl)-benzenesulfonamide (Intermediate 254) (370 mg, 0.86 mmol), SnCl2 (967 mg, 5.15 mmol), conc.HCl (4-5 drops) and EtOH (15 ml) gave the title compound (340 mg, 98%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-c1a0da29c6d94c28aa086aaa699ca013 |
| Source note | uspto-grants-2015_08 |