HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-4-chloro-N-(5-cyano-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | 4-Chloro-N-(5-cyano-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68183440 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-4-chloro-N-(5-cyano-quinolin-8-yl)-benzenesulfonamide | HCID 68183279 | 139.4% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, 4-chloro-N-(5-cyano-quinolin-8-yl)-2-nitro-benzenesulfonamide (Intermediate 273) (90 mg, 0.2 mmol), SnCl2 (28 mg, 1.3 mmol), 6N HCl (cat) and EtOH (6 ml) at 85° C. for 3 h gave the title compound (100 mg) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-8f0ff6b40da04a69803557faf3c2deb3 |
| Source note | uspto-grants-2015_08 |