HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous Chloride → 2-Amino-N-(5-fluoro-quinolin-8-yl)-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous Chloride | HCID 24479 | — |
| Reactant | N-(5-Fluoro-quinolin-8-yl)-2-nitro-benzenesulfonamide | HCID 68183367 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Amino-N-(5-fluoro-quinolin-8-yl)-benzenesulfonamide | HCID 68183209 | 82% |
Reaction Steps
In a similar fashion using route 1 general procedure 4, N-(5-Fluoro-quinolin-8-yl)-2-nitro-benzenesulfonamide (Intermediate 245) (470 mg, 1.35 mmol), SnCl2 (770 mg, 4.06 mmol), 6N HCl (6 drops) and EtOH (10 ml) for 6 h at 85° C. gave the title compound (350 mg, 82%) which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09102688B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-9e6b82ead5744d98b8143826d127975d |
| Source note | uspto-grants-2015_08 |